![]() This procedure is also available at Health Sciences Centre Winnipeg through the same MESCAMS trial. This is a complex treatment with significant side effects (patients should discuss this in detail with their neurologist). Then they receive an intravenous infusion of their previously frozen HSCs, which expand in the body to give rise to a new immune system that no longer attacks the brain and spinal cord. The patient then receives strong chemotherapy to completely eliminate their existing, defective immune system. Using chemotherapy and a stimulating drug, the patient’s own HSCs are mobilized from the bone marrow into the bloodstream where they are extracted and purified in a specialized laboratory and then frozen. The first step is to obtain the cells capable of replacing the defective immune system. The MSCs are maintained frozen, and later thawed, then infused back into the same patient, intravenously. MSCs are extracted from the patient’s own bone marrow and expanded over several weeks in a specialized culture laboratory. The new immune system no longer attacks the brain and spinal cord. These cells can be found in adult bone marrow and blood, as well as umbilical cord blood, and they can give rise to all of the cells that make up the blood and immune system. A new immune system is regenerated from Hematopoietic Stem Cells, or HSCs. This procedure uses very high doses of chemotherapy and antibodies to eliminate the defective immune system. reduce inflammation) and release factors that help prevent and repair tissue damage. Although they can give rise to other cell types, their therapeutic potential seems to come more from their ability to modify the immune system (i.e. These cells can be found in adult bone marrow, fat and skin tissue, as well as umbilical cord blood. This procedure uses Mesenchymal Stem Cells, which are also called Mesenchymal Stromal Cells or MSCs. What type of stem cell is used and how do these cells work? This treatment is currently available for appropriate patients. ![]() The Ottawa Hospital has performed a clinical trial of this treatment (summarized at in trial NCT01099930), which has now been completed. People with MS who have had significant disability for a long time would likely not benefit. This therapy is used only for patients with aggressive (but still early) forms of MS in whom existing therapies have not thoroughly contained disease activity. This trial can only accept patients (aged 18 to 50) with relapsing-remitting MS in whom at least one of the existing therapies has not thoroughly contained disease activity, as well as those with secondary and primary progressive forms of MS that continue to have active disease activity.įor detailed inclusion and exclusion criteria, see trial NCT02239393 at. This therapy is experimental, and is only available through participation in the MESCAMS clinical trial. ![]() Immunoablation and Autologous Hematopoietic Stem Cell Transplantation The other therapy being offered (Mesenchymal Stem Cell Therapy) is still experimental, but the hope is that it will reduce the immune system’s attack on the body and help repair nerve tissue. One of the therapies available at The Ottawa Hospital (called Immunoablation and Autologous Hematopoietic Stem Cell Transplantation) works by completely eliminating the body’s defective immune system and replacing it with a new healthy one derived from the body’s own bone marrow-derived hematopoietic stem cells. To understand these therapies, it is important to note that MS is an autoimmune disease that develops sometime after birth, when the body’s immune system mistakenly attacks the brain and spinal cord. If you think you may be eligible for one of these treatments, you should discuss the possibility with your neurologist and ask for a referral to The Ottawa Hospital’s MS Clinic (if you are not already a patient here). This page is meant to help people understand the two kinds of stem cell therapies available for MS at The Ottawa Hospital. Stem cell therapy holds promise for the treatment of multiple sclerosis (MS), but it can be difficult for patients to find reliable information about the types of therapies available, their possible benefits and risks, and how to access these therapies.
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![]() Just getting started with Git? The git-scm website is a good place to start, with a popular online book, Getting Started videos and cheat sheets. Many other source control providers are available through extensions on the VS Code Marketplace. Visual Studio Code has integrated source control management (SCM) and includes Git support out-of-the-box. Configure IntelliSense for cross-compiling.The option of “-vv” is just useful because it shows not only local branches, but the corresponding upstream branch for each local branch. The option of “-a” is to show all the local branches including the remote tracking branches. Remotes/origin/master 70e55da Merge branch 'feature/new-func' * master 70e55da Merge branch 'feature/new-func' Try the command to check it: $ git branch -avv If you have pushed a local branch to a remote (or fetched a branch from a remote, ) you should have a remote tracking branch that is tracking the remote’s branch with the same branch anme. So they are basically treated differently than your local branches. Since a remote tracking branch is just like a mirrored version of a branch that exists on a remote repository, it’s not something you edit or work on. If you’re not so familiar with the term “remote tracking branch”, maybe you might want to know more about it.Ī remote tracking branch is a “reference” to a branch on a remote repository. The remote tracking branch updated by “git fetch” In the above case, what’s actually merged in “origin/master”. There’s should be some set of commit SHA1 and ref names written in a text file. JFYI, FETCH_HEAD is the reference to the commits that have been fetched when you have run “git fetch”. and (2) is the merge of the remote tracking branch into the local branch. (1) git fetch updates the remote tracking branch. and this is exactly what’s executed when you run “git pull origin master” // 1) Fetch the master from origin Well, getting back from the digression, as you see in the above figure, “git pull” is a short hand of “git fetch” and “git merge”. But the command shown above does almost the same thing. What exactly is going on?Īgain, there’s no command options like “git pull -force”. ![]() However, I bet it’ll do what exactly you want to do, “git pull -force”, that is. # 2) Force the local master to "origin/master"Īs you see, this is not a command with “git pull” at all. # 1) Fetch commits on "origin", and update all your remote tracking reference So, check out the command below. Be sure you are on your local master branch before the execution. But there’s not an option like “git pul -force”. The questions is, “is it possible to FORCE the execution of git pull?” ![]() Now, you will start to think about a way of forcing git pull. Overwrite the local with the remote’s master”. When you see this message, maybe you’ll think: “All I need to do is, just make the local master up to date. ![]() , that word has never been comfortable for me, or maybe it’s not for any developer. Remote: Total 5 (delta 3), reused 0 (delta 0)ĬONFLICT (content): Merge conflict in index.phpĪutomatic merge failed fix conflicts and then commit the result.Ĭonflict. Remote: Compressing objects: 100% (5/5), done. So, it’s always frustrating to see an error message like this: $ git pull “git pull” is the most useful Git command when you’re merging any update made on the remote’s master that the local branch is maybe following. Conflict between a local branch and a remote branch However, techies believe that CPU temperature between 45-65 degrees is healthy too.Īnything beyond this implies that your Mac needs immediate attention. It’s ideal for expecting your system to be at room temperature, which I believe should be between 20-24 degrees. What are the ideal CPU temperature and fan speed on Mac? But before that, let’s understand the ideal temp and speed. Scroll through to learn everything about how to check CPU temperature and fan speed on Mac. Though there’s an activity monitor to extract some key metrics, you might need to resort to third-party apps for detailed insights into the CPU temp and fan speed of Mac. It could be the loud noises that the fan is making, the heating problem, or well, just your curiosity. Press the same button "Stop Log" to stop logging.Checking Mac’s CPU temperature and fan speed isn’t something that’s often required until something goes wrong.
Silkscreen Expanded followed from Silkscreen as an alternative with more spacing in between the letters. I wanted a font that was narrower and included a bold version. I've been using a font called Sevenet (derived from Joe Gillespie's excellent Mini7) for a while now, but I didn't quite like the look of it.too wide. Ray used his copy of Fontographer to make Mac versions of Silkscreen. I then sent the Windows TrueType versions to Ray theMaxx for some conversion. When the characters were finished for all four fonts, I generated Windows TrueType versions of them. ![]() I could have imported the letters as bitmaps, but I wanted to make Silkscreen as precise as possible and also wanted to learn as much as I could about Fontographer. Then I formed the characters into short sentences to determine the spacing for each character.Īfter all the characters were designed in Photoshop, I drew the fonts by hand in Fontographer. After drawing out each character, I played around with different letterforms on several characters before finalizing each one. It turned out that the largest characters were 5x5 pixels (not counting the ascenders and descenders), but most were 4x5 pixels. For each character, I tried to make it as skinny and short as I could. Silkscreen was designed from scratch using Adobe Photoshop 5.02 and Macromedia Fontographer 3.52 on Windows NT 4.0.įirst I used the pencil tool in Photoshop to draw all of the letters. You may have seen Silkscreen on sites such as: Flickr,, Herman Miller Store, Jeffrey Zeldman Presents,, Britney Spears, Volvo Cars, (an experimental site by Adobe), and in The Bourne Legacy. Silkscreen is a popular font and is used on quite a few Web sites. ![]() Note that I did not say "installation problems".consult your system's help files for assistance in installing fonts. You should especially let me know of any problems you encounter when using Silkscreen. Sure! Send your feedback (good or bad) to Please read the rest of the FAQ before emailing though. ![]() There is more information about Silkscreen in the FAQ below.ĭownload Silkscreen for Windows, OS X, or Linux Frequently Asked Questions about Silkscreen Silkscreen works on the Mac, Linux, and Windows and is free for personal and corporate use. Silkscreen is a typeface for your Web graphics created by Jason Kottke. ![]() Luminar Neptune is available now from the Macphun website at an introductory price of US$69. ![]() Here’s a video from Macphun demonstrating the Accent AI filter.įind out more about Luminar’s 300+ tools and features here. Local history – Provision for reviewing separate history while in Transform, Denoise, Clone & Stamp modes helps optimize editing.Crop tool update – Ability to specify custom crop sizes bring the ultimate usefulness to cropping.User Interface changes – Extensive improvements to in-app animation and mode transitions make for a more pleasing editing experience.Memory management – Increased overall performance for large files and allowance for more than five simultaneous open images.Brush, Gradient and Radial Gradient tools – These have been upgraded with faster performance for smoother selective editing.Plug-in integration with Creative Kit and Aurora HDR 2017 – Seamlessly access favorite features from Macphun’s other photo editing tools.Also improved, is the Vignette filter, with the addition of vignette styles, the option to place the center of the vignette and pre and post-crop modes to give you even more control over the final finish of your photos. Looking at the examples on their webpage, it seems like the software automatically tries to get you a HDR-like end result that you can adjust by way of a slider.Ī new workspace called “Quick & Awesome” has also been added, putting three filters – Clarity, Saturation & Vibrance, and the above mentioned Accent AI for quick and easy edits. Chief of which, is their Accent AI filter which automatically applies filters to any image for optimal effect. Macphun’s latest update to their Lumina photo-editing software for Mac brings a host of new features and updates. The latest version of Macphun’s Luminar photo-editing tool retouches photos for you ![]() ![]() You can also pick up health restoratives and a temporary shield, but the former has a tendency of popping up either too late or too close to another health item. The basic upgrade generally adds more projectiles for a wider spread the fire upgrade does more immediate single-target damage the wind upgrade does more continuous damage when you land a shot, or even creates something of a homing shot, depending on the character wielding it. You can pick up three different types of weapon upgrades that stack multiple times. Much of the gameplay loop involves running through forests, temples, and mountains as you shoot at enemies and deflect their bullets back at them. What’s interesting is that the character you play changes with every stage, so there’s a little bit of variety as you make your way to the final boss in stage 9. Early on you learn that the villain Black Mantle, from previous games in the series, has made his nefarious return, and so much of the game sees you in hot pursuit. The story begins with Rocky rushing back to the shrine to tell Pocky that monsters from the mountain have started attacking, to which Pocky responds, “But why? They promised not to be bad anymore.” Even though this line definitely got a chuckle out of me, without a way to speed up the dialogue without skipping it entirely, it becomes a chore to sit through the lengthy cutscenes that bookend each of the game’s stages. ![]() While guiding the shrine maiden, raccoon, and their pals through nine total stages is fun enough, the poor writing during cutscenes and odd way of locking content prevent this blast from Taito’s past from being a must-play. Having played both games around the time of their original release, I was looking forward to the traditional Japanese setting of Pocky & Rocky Reshrined, with its focus on Japanese mythology and challenging shooter-style gameplay. The original Pocky & Rocky, which itself was a sequel to Taito's arcade game KiKi KaiKai ( Knight Boy), was an obscure shoot'em up on foot in a Japanese setting that has since gotten a bit of a cult following since its release, and honestly I think it's a bit of an underrated game.Even though the series first appeared in Japanese arcades in 1986 as Kiki Kaikai, Nintendo fans probably know the pair of titular characters from their two adventures on the SNES, Pocky & Rocky and Pocky & Rocky 2. Pocky & Rocky's strengths were its charm, its intuitive gameplay, its surprisingly arcade-like quality, its difficulty which gradually increased the farther you progressed, two very likable and endearing main characters, a good amount of atmosphere, its nonstop quirkiness, a great sense of fun, and a really good soundtrack. =) Some gamers compare it to Konami's vastly overrated (in my opinion) The Legend of the Mystical Ninja, which is understandable considering some of both titles' similar themes, cultural settings, and levels of quirkiness. Unlike said competition, it didn't really get well-known by a lot of gamers at the time but despite that, Natsume figured that perhaps a sequel wouldn't be a bad idea, which we all got in 1994 (and for some reason it was released in Europe by Ocean). Oh, but they didn't just make a sequel, they made some substantial changes in the process so without further ado, let's talk about Pocky & Rocky 2, the least known of the two titles. ![]() ![]() Have you heard about War Mongrels Limited Edition Starter Pack? Not yet? Well, then here we are with a brand new video showing you all the wonderful items you will find inside! Tempted? You should be. ![]() War Mongrels: Limited Edition Starter Pack And as the goal of every hero is to save others and hopefully survive, our heroes strive to prevent the deaths of innocent people instead of getting away from the war as originally intended. War Mongrels is a real-time tactics game from the creators of Ancestors Legacy, thats trying to show a side thats not as represented as much in strategy. Dynamic and tactical gameplay with stealth elements, tightly packed into a dark, fascinating story Play on your own or in online co-op. Sneaking, distraction, silent kills, and using the environment are some of the main skills players will have to take to heart, but a stock of firearms will also be available and useful in completing mission objectives. War Mongrels is an isometric real-time tactics game that takes place on the eastern front of World War II. As each character has their own set of skills and advantages, players must learn to combine them effectively to outsmart the enemy during a variety of missions in a changing environment. Firstly About War Mongrels interesting Game That is to say: This game is a real-time tactical game that focuses on stealth and strategy. Their team expands as they meet new characters who support the same cause. The heavily history-inspired storyline guides players through the journey of two Wehrmacht soldiers as they go from deserters to hefty guerilla fighters. and the Mongrel Mob are two of New Zealands largest and wage war on the. The recent patch that addressed prior issues with saves, AI and several others. From boys to men in days, they open their eyes to the atrocities of war and find their purpose in the fight to prevent further meaningless killing. 1 Law enforcement officials estimate approximately 2,000 full-patched members. War Mongrels, the brutally accurate isometric real-time tactics game from. First driven by propaganda, our heroes soon find their purpose in fighting back the expanding Nazi forces that entangled them in the international conflict in the first place. Mongrels builds its foundations on these two opposing mental forces. You can access and control your synced folders from the OmniPresence popover in the menubar: Otherwise, click Done to close the menu, or click Open Synced Folder to open the newly synced folder in a Finder window.
What should I do if my iron has not been used for a long time?
![]() Search for treasure, explore the islands and find upgrades for your ship. This is very useful when the market is oversaturated with certain kinds of products and their price is falling.ĭon't let magical forces stand in your way as you encounter secret totems, living voodoo dolls and ancient pyramids.įace pirates in sea battles, keep your cool and give orders to your crew to emerge victorious.Ĭarve your own path through the jungles, swamps, hills and deserts of the Caribbean!Ĭollect resources, construct buildings and set up production chains so that you can manufacture more complex – and valuable – goods. Every building can be torn down and replaced with a new one. For example, you can make bread from cornflower by building a special building and having a small amount of gold and an available worker. As well as building a farm, quarry and forest hut, you can also construct processing buildings, whose output is more expensive and better-suited for future production. Of course, the settlers will also have to build bridges and roads, clear obstacles and sell the resources they collect. Unlike other games in the genre, Merchants of the Caribbean places an emphasis on trade. Luckily, your crew includes the delightful sorceress Tamika, who has a score to settle with Fallen Henry. On your journey, you'll encounter not only rockslides and economic troubles, but also magic - including enchanted totems, voodoo and ancient pyramids. And now the young trader must beat the pirate in the race for the secret treasure chest! In the thick of battle, the wicked pirate manages to tear off part of a real treasure map that miraculously ended up with Jack. However, the greedy pirate Fallen Henry stands between Savvy and his success, attacking him for his ship and resources. Although players can kill each other, there is no player elimination as players may draw a new captain (with a penalty) so it's possible to come back from defeat.Young Englishman Jack Savvy decides to launch a trade empire in the Caribbean. Both careers are fraught with danger: pirates are hunted by NPCs (and other players) for their bounty and blocked to certain ports while traders are hunted by non-player pirates as well as their opponents and generally have to sacrifice combat capability for cargo capacity. Points due to gold are hidden so there's some uncertainty about when the game will end.Ī big component of the game is whether (or when) to turn "pirate" or remain as a trader or neutral party. While some points earned from performing various tasks are permanent, players earn points for amassing gold, which can be stolen or lost (or at least diminished) if their captain is killed. ![]() ![]() The goal is to be the first to achieve 10 "glory" points through performing daring deeds (through the completion of missions or rumors), crushing your enemies (through defeating opponents and NPCs in combat), amassing gold, performing an epic plunder or pulling off the trade of a lifetime, and buying a grand ship. In Merchants and Marauders, players take on the role of a captain of a small vessel in the Caribbean. Will your captain gain eternal glory and immense wealth - or find his wet grave under the stormy surface of the Caribbean Sea? Modify your ship, buy impressive vessels, load deadly special ammunition, and hire specialist crew members. Seek your fortune through trade, rumor hunting, missions, and of course, plundering. Merchants & Marauders lets you live the life of an influential merchant or a dreaded pirate in the Caribbean during the Golden Age of Piracy. Top Cashback is currently offering £15 cashback on a whole load of gaming-related purchases when you pick up goodies from specified merchants, including Nintendo Store, Currys, Argos, Game and. |